WJ-MSCs, cells at the heart of StemInov's innovation, are a particular type of adult MSC, of which several types have been described according to their location in the body and their origin in foetal (Wharton's jelly) or adult tissues (two main sources are bone marrow (BM), adipose tissue (AT)).

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Thanks to their properties (figure below) Mesenchymal stem cells (MSCs) are a critical raw material for many regenerative medicine products, including cell-based therapies, engineered tissues, or combination products. Indeed, MSCs modulate the host immune systems, e.g., by secreting various trophic factors. Thereby, they reduce inflammation, promote neoangiogenesis, and prevent apoptosis and fibrosis. Additionally, they stimulate local stem cells to develop new tissue.

 

Furthermore, as they do not express major histocompatibility complex (MHC) class II molecules and have only low levels of MHC class I, MSCs are poorly immunogenic cells and therefore potentially usable in an allogeneic situation (where the donor is a different person from the patient), which makes them particularly attractive for clinical use.